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管代禄

发布者:dongke发布时间:2026-04-20浏览次数:11


管代禄,男,汉族,19926月生,重庆人,中共党员,博士研究生学历,教授,博、硕导。

工作单位 华南农业大学动物科学学院

邮政编码510642

通讯地址 广州市天河区五山路483

邮箱地址dguan@scau.edu.cn

实验室主页guandailu.org


个人简介:

华南农业大学动物科学学院教授、博士生导师。长期致力于揭示遗传变异如何塑造表型多样性,通过整合数量遗传学、生物信息学、计算生物学与机器学习等方法,构建三大协同研究方向:1)整合单细胞与多组学系统性解析遗传变异在不同组织、细胞类型、发育阶段及疾病等状态下影响复杂表型的分子机制;2)利用人工智能等新兴技术构建基因组大语言模型、虚拟细胞或器官等,实现生物系统的数字化模拟与精准干预;3)通过比较基因组学方法揭示品种或物种间调控表型的基因保守性与分化规律。研究成果为表型形成机制提供基础性见解,并为智慧农业与精准育种提供转化工具。相关成果发表于《Nature Genetics》《Journal of Animal Science and Biotechnology》《Genetics Selection Evolution》《Journal of Dairy Science》等国内外高水平学术期刊,公开发表论文40余篇。



工作经历

2026/04 –至今华南农业大学动物科学学院教授

2024/09 – 2026/02加州大学戴维斯分校动物科学系助理研究员

2021/03 – 2024/09加州大学戴维斯分校动物科学系博士后研究员



教育经历

2017/09 – 2020/12巴塞罗那自治大学畜牧学博士

2014/09 – 2017/06西南大学动物遗传育种与繁殖硕士

2010/09 – 2014/06西南大学动物科学学士


研究领域

  1. 解析复杂表型背后的遗传调控机制。

  2. 人工智能驱动的生物系统数字化模拟。

  3. 比较基因组学与基因调控进化。


发表论文

2026

  1. Y. Hou, D. Zou, Q. Chu, B. Zhan, R. Wang,D. Guan#, W. Wang, X. Feng, X. Li, X. Zhu, Z. Bai, Y. Gao, H. Yin, T. Xu, Z. Yuan, X. Hu, N. Yang, H. Zhou, L. Fang, Z. Zhang, The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity.Nucleic Acids Res 54, D982–D993 (2026).


  1. B. Zhao, H. Luo,D. Guan, X. Fu, F. Wang, G. Zhang, S. Li, H. Yang, Y. Zhang, Comparative Single-Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits.Advanced Science 13, e17633 (2026).


  1. T. F. Cardoso, M. G. Luigi-Sierra, A. Noce, M. Wang,D. Guan, E. Casas, S. Olvera-Maneu, J. Gardela, E. Mármol-Sánchez, M. López-Béjar, M. Amills, Pregnancy induces extensive changes of transcript usage in the goat brain.Journal of Dairy Science 109, 2004–2022 (2026).

2025

  1. D. Guan, Z. Bai, X. Zhu, C. Zhong, Y. Hou, D. Zhu, H. Li, F. Lan, S. Diao, Y. Yao, B. Zhao, X. Li, Z. Pan, Y. Gao, Y. Wang, D. Zou, R. Wang, T. Xu, C. Sun, H. Yin, J. Teng, Z. Xu, Q. Lin, S. Shi, D. Shao, F. Degalez, S. Lagarrigue, Y. Wang, M. Wang, M. Peng, D. Rocha, M. Charles, J. Smith, K. Watson, A.J. Buitenhuis, G. Sahana, M.S. Lund, W. Warren, L. Frantz, G. Larson, S.J. Lamont, W. Si, X. Zhao, B. Li, H. Zhang, C. Luo, D. Shu, H. Qu, W. Luo, Z. Li, Q. Nie, X. Zhang, R. Xiang, S. Liu, Z. Zhang, Z. Zhang, G.E. Liu, H. Cheng, N. Yang, X. Hu, H. Zhou, L. Fang, Genetic regulation of gene expression across multiple tissues in chickens,Nature Genetics (2025) 1–11. https://doi.org/10.1038/s41588-025-02155-9.


  1. H. Yin, L. Yang, Q. Zhao, W. Yao, J. Teng, Y. Gao, Z. Xu, Q. Lin, S. Diao, X. Liu, F. Zhao, Z. Zhou, Q. Wang, J. Li, Z. Zhang, H. Zhou, M.A.M. Groenen, O. Madsen, L. Bai,D. Guan*, L. Fang, K. Li, Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs,BMC Biology 23 (2025) 188. https://doi.org/10.1186/s12915-025-02279-8.


  1. B. Zhao, K. Dai, S. Li, G. Zhang, W. Lv, W. Liu, Y. Cai, F. Wang, H. Zhou,D. Guan*, Y. Zhang, Integrative single-cell transcriptomics of sheep ovarian development reveals dynamic transcriptional programs relevant to reproductive traits,iScience 28 (2025). https://doi.org/10.1016/j.isci.2025.112422. IF = 4.1


  1. H. Zhou, E. Clark,D. Guan, S. Lagarrigue, L. Fang, H. Cheng, C.K. Tuggle, M. Kapoor, Y. Wang, E. Giuffra, G. Egidy, Comparative Genomics and Epigenomics of Transcriptional Regulation,Annual Review of Animal Biosciences 13 (2025) 73–98. https://doi.org/10.1146/annurev-animal-111523-102217.


  1. L. Fang, J. Teng, Q. Lin, Z. Bai, S. Liu,D. Guan, B. Li, Y. Gao, Y. Hou, M. Gong, Z. Pan, Y. Yu, E.L. Clark, J. Smith, K. Rawlik, R. Xiang, A.J. Chamberlain, M.E. Goddard, M. Littlejohn, G. Larson, D.E. MacHugh, J.F. O’Grady, P. Sørensen, G. Sahana, M.S. Lund, Z. Jiang, X. Pan, W. Gong, H. Zhang, X. He, Y. Zhang, N. Gao, J. He, G. Yi, Y. Liu, Z. Tang, P. Zhao, Y. Zhou, L. Fu, X. Wang, D. Hao, L. Liu, S. Chen, R.S. Young, X. Shen, C. Xia, H. Cheng, L. Ma, J.B. Cole, R.L. Baldwin, C. Li, C.P. Van Tassell, B.D. Rosen, N. Bhowmik, J. Lunney, W. Liu, L. Guan, X. Zhao, E.M. Ibeagha-Awemu, Y. Luo, L. Lin, O. Canela-Xandri, M.F.L. Derks, R.P.M.A. Crooijmans, M. Gòdia, O. Madsen, M.A.M. Groenen, J.E. Koltes, C.K. Tuggle, F.M. McCarthy, D. Rocha, E. Giuffra, M. Amills, A. Clop, M. Ballester, G. Tosser-Klopp, J. Li, C. Fang, M. Fang, Q. Wang, Z. Hou, Q. Wang, F. Zhao, L. Jiang, G. Zhao, Z. Zhou, R. Zhou, H. Liu, J. Deng, L. Jin, M. Li, D. Mo, X. Liu, Y. Chen, X. Yuan, J. Li, S. Zhao, Y. Zhang, X. Ding, D. Sun, H.-Z. Sun, C. Li, Y. Wang, Y. Jiang, D. Wu, W. Wang, X. Fan, Q. Zhang, K. Li, H. Zhang, N. Yang, X. Hu, W. Huang, J. Song, Y. Wu, J. Yang, W. Wu, C. Kasper, X. Liu, X. Yu, L. Cui, X. Zhou, S. Kim, W. Li, H.K. Im, E.S. Buckler, B. Ren, M.C. Schatz, J.J. Li, A.A. Palmer, L. Frantz, H. Zhou, Z. Zhang, G.E. Liu, The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project,Nat Genet (2025) 1–11. https://doi.org/10.1038/s41588-025-02121-5.


  1. W. Wang, C. Shen, X. Wen, A. Li, Q. Gao, Z. Xu, Y. Wei, Y. Li,D. Guan, B. Liu, Prediction of transcript isoforms and identification of tissue-specific genes in cucumber,BMC Genomics 26 (2025) 25. https://doi.org/10.1186/s12864-025-11212-w.


  1. T.S. Kalbfleisch, S.D. McKay, B.M. Murdoch, D.L. Adelson, D. Almansa-Villa, G. Becker, L.M. Beckett, M.J. Benítez-Galeano, F. Biase, T. Casey, E. Chuong, E. Clark, S. Clarke, N. Cockett, C. Couldrey, B.W. Davis, C.G. Elsik, T. Faraut, Y. Gao, C. Genet, P. Grady, J. Green, R. Green,D. Guan, D. Hagen, G.A. Hartley, M. Heaton, S.J. Hoyt, W. Huang, E. Jarvis, J. Kalleberg, H. Khatib, K.-P. Koepfi, J. Koltes, S. Koren, C. Kuehn, T. Leeb, A. Leonard, G.E. Liu, W.Y. Low, H. McConnell, K. McRae, K. Miga, M. Mousel, H. Neibergs, T. Olagunju, M. Pennell, B. Petry, M. Pewsner, A.M. Phillippy, B.D. Pickett, P. Pineda, T. Potapova, S. Rachagani, A. Rhie, M. Rijnkels, A. Robic, N. Rodriguez Osorio, Y. Safonova, G. Schettini, R.D. Schnabel, N. Sirpu Natesh, M. Stegemiller, J. Storer, P. Stothard, C. Stull, G. Tosser-Klopp, G.M. Traglia, C.K. Tuggle, C.P. Van Tassell, C. Watson, R. Weikard, K. Wimmers, S. Xie, L. Yang, T.P.L. Smith, R.J. O’Neill, B.D. Rosen, The Ruminant Telomere-to-Telomere (RT2T) Consortium,Nature Genetics (2024) 1–8. https://doi.org/10.1038/s41588-024-01835-2. IF = 29


  1. D. Zhu, K. Shi, C. Li, Y. Yan, H. Li, Z. Bai, L. Tan,D. Guan, Y. Zhao, Y. Wang, B. Fan, Z. Jiang, Z. Xu, C. Feng, L. Fang, X. Hu, Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits.Nature Communications 17, 553 (2025).

2024

  1. C. Zhong, X. Li,D. Guan, B. Zhang, X. Wang, L. Qu, H. Zhou, L. Fang, C. Sun, N. Yang, Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses,Journal of Genetics and Genomics51 (2024) 1423–1434. https://doi.org/10.1016/j.jgg.2024.09.003.


  1. J. Teng, Y. Gao, H. Yin, Z. Bai, S. Liu, H. Zeng, L. Bai, Z. Cai, B. Zhao, X. Li, Z. Xu, Q. Lin, Z. Pan, W. Yang, X. Yu,D. Guan, Y. Hou, B.N. Keel, G.A. Rohrer, A.K. Lindholm-Perry, W.T. Oliver, M. Ballester, D. Crespo-Piazuelo, R. Quintanilla, O. Canela-Xandri, K. Rawlik, C. Xia, Y. Yao, Q. Zhao, W. Yao, L. Yang, H. Li, H. Zhang, W. Liao, T. Chen, P. Karlskov-Mortensen, M. Fredholm, M. Amills, A. Clop, E. Giuffra, J. Wu, X. Cai, S. Diao, X. Pan, C. Wei, J. Li, H. Cheng, S. Wang, G. Su, G. Sahana, M.S. Lund, J.C.M. Dekkers, L. Kramer, C.K. Tuggle, R. Corbett, M.A.M. Groenen, O. Madsen, M. Gòdia, D. Rocha, M. Charles, C. Li, H. Pausch, X. Hu, L. Frantz, Y. Luo, L. Lin, Z. Zhou, Z. Zhang, Z. Chen, L. Cui, R. Xiang, X. Shen, P. Li, R. Huang, G. Tang, M. Li, Y. Zhao, G. Yi, Z. Tang, J. Jiang, F. Zhao, X. Yuan, X. Liu, Y. Chen, X. Xu, S. Zhao, P. Zhao, C. Haley, H. Zhou, Q. Wang, Y. Pan, X. Ding, L. Ma, J. Li, P. Navarro, Q. Zhang, B. Li, A. Tenesa, K. Li, G.E. Liu, Z. Zhang, L. Fang, A compendium of genetic regulatory effects across pig tissues,Nature Genetics 56 (2024) 112–123. https://doi.org/10.1038/s41588-023-01585-7.


  1. M.G. Luigi-Sierra, Y. Ramayo-Caldas,D. Guan, M. Amills, Short communication: Comparing the microbiota diversity from the core, middle part and rind of six Spanish commercial goat cheeses,Livestock Science 285 (2024) 105496. https://doi.org/10.1016/j.livsci.2024.105496.


  1. B. Liu, C.-C. Shen, S.-W. Xia, S.-S. Song, L.-H. Su, Y. Li, Q. Hao, Y.-J. Liu, D.-L. Guan, N. Wang, W.-J. Wang, X. Zhao, H.-X. Li, X.-X. Li, Y.-S. Lai, A nanopore-based cucumber genome assembly reveals structural variations at two QTLs controlling hypocotyl elongation,Plant Physiology 195 (2024) 970–985. https://doi.org/10.1093/plphys/kiae153.


  1. E. Varela-Martínez, M.G. Luigi-Sierra,D. Guan, M. López-Béjar, E. Casas, S. Olvera-Maneu, J. Gardela, M.J. Palomo, U.I. Osuagwuh, U.L. Ohaneje, E. Mármol-Sánchez, M. Amills, The landscape of long noncoding RNA expression in the goat brain,Journal of Dairy Science 107 (2024) 4075–4091. https://doi.org/10.3168/jds.2023-23966.


  1. L. Yang, H. Yin, L. Bai, W. Yao, T. Tao, Q. Zhao, Y. Gao, J. Teng, Z. Xu, Q. Lin, S. Diao, Z. Pan,D. Guan, B. Li, H. Zhou, Z. Zhou, F. Zhao, Q. Wang, Y. Pan, Z. Zhang, K. Li, L. Fang, G.E. Liu, Mapping and functional characterization of structural variation in 1060 pig genomes,Genome Biology 25 (2024) 116. https://doi.org/10.1186/s13059-024-03253-3.


  1. W. Wang, Y. Wei, Z. Xu, C. Shen, A. Li,D. Guan, X. Zhang, B. Liu, Evidence Supporting a Role of Alternative Splicing Participates in Melon (Cucumis melo L.) Fruit Ripening,International Journal of Molecular Sciences 25 (2024) 5886. https://doi.org/10.3390/ijms25115886.


  1. D. Colombi, G. Rovelli, M.G. Luigi-Sierra, S. Ceccobelli,D. Guan, F. Perini, F. Sbarra, A. Quaglia, F.M. Sarti, M. Pasquini, M. Amills, E. Lasagna, Population structure and identification of genomic regions associated with productive traits in five Italian beef cattle breeds,Scientific Reports 14 (2024) 8529. https://doi.org/10.1038/s41598-024-59269-z.


  1. F. Degalez, M. Charles, S. Foissac, H. Zhou,D. Guan, L. Fang, C. Klopp, C. Allain, L. Lagoutte, F. Lecerf, H. Acloque, E. Giuffra, F. Pitel, S. Lagarrigue, Enriched atlas of lncRNA and protein-coding genes for the GRCg7b chicken assembly and its functional annotation across 47 tissues,Scientific Reports 14 (2024) 6588. https://doi.org/10.1038/s41598-024-56705-y.

2023

  1. J. Li,D. Guan#, M.M. Halstead, A.D. Islas-Trejo, D.E. Goszczynski, C.W. Ernst, H. Cheng, P. Ross, H. Zhou, Transcriptome annotation of 17 porcine tissues using nanopore sequencing technology,Animal Genetics 54 (2023) 35–44. https://doi.org/10.1111/age.13274.


  1. J. Li, T. Zhao,D. Guan, Z. Pan, Z. Bai, J. Teng, Z. Zhang, Z. Zheng, J. Zeng, H. Zhou, L. Fang, H. Cheng, Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits,Cell Genomics 3 (2023) 100390. https://doi.org/10.1016/j.xgen.2023.100390.


  1. M. Macri, M.G. Luigi-Sierra,D. Guan, J.V. Delgado, J.F. Alvarez, M. Amills, A.M. Martínez, Univariate and multivariate genome-wide association studies for hematological traits in Murciano-Granadina goats,Animal Genetics 54 (2023) 491–499. https://doi.org/10.1111/age.13328.


  1. M.G. Luigi-Sierra,D. Guan, M. López-Béjar, E. Casas, S. Olvera-Maneu, J. Gardela, M.J. Palomo, U.I. Osuagwuh, U.L. Ohaneje, E. Mármol-Sánchez, M. Amills, A protein-coding gene expression atlas from the brain of pregnant and non-pregnant goats,Frontiers in Genetics. 14 (2023). https://doi.org/10.3389/fgene.2023.1114749.


  1. Z. Pan, Y. Wang, M. Wang, Y. Wang, X. Zhu, S. Gu, C. Zhong, L. An, M. Shan, J. Damas, M.M. Halstead,D. Guan, N. Trakooljul, K. Wimmers, Y. Bi, S. Wu, M.E. Delany, X. Bai, H.H. Cheng, C. Sun, N. Yang, X. Hu, H.A. Lewin, L. Fang, H. Zhou, An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics,Science Advances 9 (2023) eade1204. https://doi.org/10.1126/sciadv.ade1204.


  1. J.C. Lin, T.F. Bishop, J.R. Owen, S.L. Hennig, D.S. Fitzpatrick, M.L. Mueller,D. Guan, M.L. Angove, A. Hua, E.G. Balogh, R.J. Swift, P.J. Ross, A.L. Van Eenennaam, Optimization of Electroporation and Adeno-Associated Virus-Mediated Generation of 2.7 kb Knock-In Livestock Blastocysts,GEN Biotechnology 2 (2023) 120–132. https://doi.org/10.1089/genbio.2022.0037.

2022

  1. D. Guan, M.M. Halstead, A.D. Islas-Trejo, D.E. Goszczynski, H.H. Cheng, P.J. Ross, H. Zhou, Prediction of transcript isoforms in 19 chicken tissues by Oxford Nanopore long-read sequencing,Frontiers in Genetics. 13 (2022). https://doi.org/10.3389/fgene.2022.997460.


  1. S. Liu, Y. Gao, O. Canela-Xandri, S. Wang, Y. Yu, W. Cai, B. Li, R. Xiang, A.J. Chamberlain, E. Pairo-Castineira, K. D’Mellow, K. Rawlik, C. Xia, Y. Yao, P. Navarro, D. Rocha, X. Li, Z. Yan, C. Li, B.D. Rosen, C.P. Van Tassell, P.M. Vanraden, S. Zhang, L. Ma, J.B. Cole, G.E. Liu, A. Tenesa, L. Fang, A multi-tissue atlas of regulatory variants in cattle,Nature Genetics 54 (2022) 1438–1447. https://doi.org/10.1038/s41588-022-01153-5.


  1. M.G. Luigi-Sierra, A. Fernández, A. Martínez,D. Guan, J.V. Delgado, J.F. Álvarez, V. Landi, F.X. Such, J. Jordana, M. Saura, M. Amills, Genomic patterns of homozygosity and inbreeding depression in Murciano-Granadina goats,Journal of Animal Science and Biotechnology 13 (2022) 35. https://doi.org/10.1186/s40104-022-00684-5.

2021

  1. D. Guan, A. Castelló, M.G. Luigi-Sierra, V. Landi, J.V. Delgado, A. Martínez, M. Amills, Estimating the copy number of the agouti signaling protein (ASIP) gene in goat breeds with different color patterns,Livestock Science 246 (2021) 104440. https://doi.org/10.1016/j.livsci.2021.104440.


  1. D. Guan, A. Martínez, M.G. Luigi-Sierra, J.V. Delgado, V. Landi, A. Castelló, J. Fernández Álvarez, X. Such, J. Jordana, M. Amills, Detecting the footprint of selection on the genomes of Murciano-Granadina goats,Animal Genetics 52 (2021) 683–693. https://doi.org/10.1111/age.13113.


  1. B. Liu, J. Weng,D. Guan, Y. Zhang, Q. Niu, E. López-Juez, Y. Lai, J. Garcia-Mas, D. Huang, A domestication-associated gene, CsLH, encodes a phytochrome B protein that regulates hypocotyl elongation in cucumber,Molecular Horticulture1 (2021) 3. https://doi.org/10.1186/s43897-021-00005-w.


  1. E. Mármol-Sánchez, M.G. Luigi-Sierra, A. Castelló,D. Guan, R. Quintanilla, R. Tonda, M. Amills, Variability in porcine microRNA genes and its association with mRNA expression and lipid phenotypes,Genetics Selection Evolution 53 (2021) 43. https://doi.org/10.1186/s12711-021-00632-3.


  1. L. Yang,D. Guan, M. Valls, W. Ding, Sustainable natural bioresources in crop protection: antimicrobial hydroxycoumarins induce membrane depolarization-associated changes in the transcriptome of,Pest Management Science 77 (2021) 5170–5185. https://doi.org/10.1002/ps.6557.


  1. G. Rovelli, M.G. Luigi-Sierra,D. Guan, F. Sbarra, A. Quaglia, F.M. Sarti, M. Amills, E. Lasagna, Evolution of inbreeding: a gaze into five Italian beef cattle breeds history,PeerJ 9 (2021) e12049. https://doi.org/10.7717/peerj.12049.

2020

  1. D. Guan, V. Landi, M.G. Luigi-Sierra, J.V. Delgado, X. Such, A. Castelló, B. Cabrera, E. Mármol-Sánchez, J. Fernández-Alvarez, J.L.R. de la Torre Casañas, A. Martínez, J. Jordana, M. Amills, Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats,Journal of Animal Science and Biotechnology 11 (2020) 35. https://doi.org/10.1186/s40104-020-00435-4.


  1. D. Guan, A. Martínez, A. Castelló, V. Landi, M.G. Luigi-Sierra, J. Fernández-Álvarez, B. Cabrera, J.V. Delgado, X. Such, J. Jordana, M. Amills, A genome-wide analysis of copy number variation in Murciano-Granadina goats,Genetics Selection Evolution 52 (2020) 44. https://doi.org/10.1186/s12711-020-00564-4.


  1. M.G. Luigi-Sierra, V. Landi,D. Guan, J.V. Delgado, A. Castelló, B. Cabrera, E. Mármol-Sánchez, J.F. Alvarez, M. Gómez-Carpio, A. Martínez, X. Such, J. Jordana, M. Amills, A genome-wide association analysis for body, udder, and leg conformation traits recorded in Murciano-Granadina goats,Journal of Dairy Science103 (2020) 11605–11617. https://doi.org/10.3168/jds.2020-18461.

2019 and before

  1. D. Guan, E. Mármol-Sánchez, T.F. Cardoso, X. Such, V. Landi, N.R. Tawari, M. Amills, Genomic analysis of the origins of extant casein variation in goats,Journal of Dairy Science 102 (2019) 5230–5241. https://doi.org/10.3168/jds.2018-15281.


  1. D. Guan, N. Luo, X. Tan, Z. Zhao, Y. Huang, R. Na, J. Zhang, Y. Zhao, Scanning of selection signature provides a glimpse into important economic traits in goats (Capra hircus),Scientific Reports 6 (2016) 36372. https://doi.org/10.1038/srep36372.


  1. B. Liu,D. Guan, X. Zhai, S. Yang, S. Xue, S. Chen, J. Huang, H. Ren, X. Liu, Selection footprints reflect genomic changes associated with breeding efforts in 56 cucumber inbred lines,Horticulture Research 6 (2019) 127. https://doi.org/10.1038/s41438-019-0209-4.



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