以下信息为主动公开的研究生招生宣传信息
目录
李紫聪   更新日期: 2023年10月12日
李紫聪,男,汉族,1979年3月生,江门台山市人,致公,博士研究生学历,名誉博士,教授,博导。
工作单位   动物科学学院动物遗传育种与繁殖系
行政职务  系主任
通讯地址  动物科学学院新楼619房
单位电话  020-85284869
邮箱地址  lizicong@scau.edu.cn
个人主页  https://dongke.scau.edu.cn/2017/0525/c10047a239868/page.psp
个人简介
李紫聪,男,留美归国博士,教授,博士生导师, 籍贯为广东省江门台山市;中国致公党华南农业大学总支部副主委;广东省农业动物基因组学与分子育种重点实验室副主任,猪禽种业全国重点实验室PI,国家生猪种业工程技术研究中心、畜禽育种国家地方联合工程研究中心、国家区域性畜禽基因库核心团队成员,广东省畜禽遗传资源委员会专业委员,中国农业生物技术学会动物生物技术分会理事,中国畜牧兽医学会养猪学分会常务理事;获国家科技进步奖二等奖、全国农牧渔丰收奖、全国高等学校科学研究优秀成果奖一等奖和广东省科学技术奖一等奖等科技奖励6项;主持国家转基因生物新品种培育科技重大专项课题,国家自然科学基金面上项目和青年基金项目等课题13项;在Elife, Journal of nanaobiotechnology等期刊发表论文100多篇,获授权发明专利30余项。
工作经历
2001年7月至2002年10月:温氏食品集团清新县太平猪场,任生产线区长;
2003年1月至2003年8月:广东中山健邦饲料科技有限公司,任技术服务员;
2011年1月至目前:华南农业大学动物科学学院,从事动物遗传育种与繁殖专业的教学和科研工作。
教育经历
1997年9月至2001年6月:华南农业大学,畜牧专业,获学士学位;
2003年9月至2006年6月:华南农业大学,动物遗传育种与繁殖专业,获硕士学位;
2006年8月至2010年10月:美国夏威夷大学(University of Hawaii),分子生物与生物工程专业,获博士学位;
获奖荣誉
1、李紫聪(7/10),高效瘦肉型种猪新配套系培育与应用,中华人民共和国国务院,国家科技进步奖,二等奖,2018.
2、李紫聪(14/20),新型高效“温氏WS501猪配套系”培育与应用,中华人民共和国教育部,高等学校科学研究优秀成果奖(科技进步类),一等奖, 2023.
3、李紫聪(7/10),高效瘦肉型种猪新配套系培育与应用,中国产学研合作促进会,中国产学研合作创新成果奖,一等奖, 2018.
4、李紫聪(2/15),种猪体细胞克隆技术研发与应用,广东省人民政府,广东省科学技术奖(科技进步类),一等奖,2016.
5、李紫聪(19/25),高效瘦肉型种猪及其养殖技术示范推广,中华人民共和国农业部,全国农牧渔业丰收奖,农业技术推广合作奖,2016.
6、李紫聪(2/20),猪克隆技术及优秀克隆种猪应用推广,广东省农业厅,广东省农业技术推广奖,一等奖,2015.

1、2012年入选广东省教育厅高校优秀青年教师人才培养计划
2、2013年入选华南农业大学青年骨干教师培养计划
3、2014年入选广东省高等学校千百十人才培养工程校级培养计划
4、2019年入选广东省高层次人才特殊支持计划“畜禽种业自主创新团队核心成员”培养计划
研究领域
1、动物体细胞克隆技术和克隆胚胎发育调控机制;
2、动物泌乳和母性行为的遗传调控机制;
科研项目
1、寻找影响猪克隆效率相关基因及通过敲除供体细胞的Xist基因提高猪克隆效率,广东温氏食品集团科研基金项目, 2010年-2012年,总经费22.85万元。
2、利用piggyBac转座子系统介导的基因转移技术提高精子载体法制备转基因猪效率的研究, 国家自然科学基金青年科学基金项目, 2012年起2014年,总经费22 万元。
3、优质环保转基因猪新品种培育,国家转基因生物新品种培育科技重大专项课题,2016年-2020年,总经费3084万元。
4、高效种猪体细胞克隆扩繁技术研究与应用示范,广东省科技计划项目,2016年-2018年,总经费15万元。
5、猪规模化高效体细胞克隆扩繁技术研发与应用,广东省 科技计划项目,2016年-2019年,总经费300万元。
6、下调组蛋白修饰H3K9me3的水平对猪克隆胚胎基因表达模式及发育效率的影响,国家自然科学基金面上项目,2018年-2021年,总经费66万元。
7、调控猪克隆胚胎发育效率的关键印记基因鉴定及高效猪克隆方法建立,广东省自然科学基金-温氏联合基金项目,2020年-2022年,总经费50万元。
8、畜禽种业自主创新团队子课题,广东特支计划本土创新创业团队项目,2020年-2025年,总经费100万元。
9、高繁大黑猪新品种培育及繁育体系构建,国家重点研发计划项目子课题,2022年-2026年,总经费420万元。
10、瘦肉型猪本土化选育提高及专门化品系培育,广东省乡村振兴战略专项种业振兴项目,2023年-2025年,总经费300万元。
发表论文
1. Hong L, Zang X, Hu Q, He Y, Xu Z, Xie Y, Gu T, Yang H, Yang J, Shi J, Zheng E, Huang S, Xu Z, Liu D, Cai G, Li Z (Co-corresponding author), Wu Z. Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation. Journal of Nanobiotechnology. 2023;21(1):79. 2022 IF=10.20.
2. Zhao H, He X, Zhang X, Shi J, Zhou R, Mai R, Su Q, Cai G, Huang S, Xu Z, Wu Z, Li Z (Corresponding author). Progesterone and Androstenedione Are Important Follicular Fluid Factors Regulating Porcine Oocyte Maturation Quality. Animals (Basel). 2023, 13(11), 1811. 2022 IF=3.231.
3. Xing X, Liang Y, Li Y, Zhao Y, Zhang Y, Li Z, Li Z (Co-corresponding author), Wu Z. Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway. Molecules. 2023;28(14):5533. 2022 IF=4.927.
4. Zhou C, Cheng X, Meng F, Wang Y, Luo W, Zheng E, Cai G, Wu Z, Li Z (Co-corresponding author), Hong L. Identification and characterization of circRNAs in peri-implantation endometrium between Yorkshire and Erhualian pigs. BMC Genomics. 2023;24(1):412. 2022 IF=4.4.
5. Peng J, Hou Y, Wu S, Li Z (Co-corresponding author), Wu Z. Knockout of Rlim Results in a Sex Ratio Shift toward Males but Superovulation Cannot Compensate for the Reduced Litter Size. Animals (Basel). 2023;13(6):1079. 2022 IF=3.231.
6. Xing X, Peng J, Zhao J, Shi R, Wang C, Zhang Z, Wang Z, Li Z (Co-corresponding author), Wu Z. Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging. Frontiers in Nutrition. 2023;10:1192758. 2022 IF=6.59.
7. Zeng F, Liao S, Kuang Z, Zhu Q, Wei H, Shi J, Zheng E, Xu Z, Huang S, Hong L, Gu T, Yang J, Yang H, Cai G, Moisyadi S, Urschitz J, Li Z (Co-corresponding author), Wu Z. Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor. Cells. 2022;11(15):2378. 2022 IF=7.666.
8. Dong Y, Wu X, Peng X, Yang L, Tan B, Zhao H, Zheng E, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Knockdown of YY1 Inhibits XIST Expression and Enhances Cloned Pig Embryo Development. International Journal of Molecular Science. 2022;23(23):14572. 2022 IF=6.208.
9. Zhang Y, Yang L, Zhang Y, Liang Y, Zhao H, Li Y, Cai G, Wu Z, Li Z (Corresponding author). Identification of Important Factors Causing Developmental Arrest in Cloned Pig Embryos by Embryo Biopsy Combined with Microproteomics. International Journal of Molecular Science. 2022;23(24):15975. 2022 IF=6.208.
10. Zhao H, Dong Y, Zhang Y, Wu X, Zhang X, Liang Y, Li Y, Zeng F, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development. Molecules. 2022;27(20):6830. 2022 IF=4.927.
11. Wang W, Zang X, Liu Y, Liang Y, Cai G, Wu Z, Li Z (Corresponding author). Dynamic miRNA Landscape Links Mammary Gland Development to the Regulation of Milk Protein Expression in Mice. Animals (Basel). 2022;12(6):727. 2022 IF=3.231
12. Tan B, Zeng J, Meng F, Wang S, Xiao L, Zhao X, Hong L, Zheng E, Wu Z, Li Z(Co-corresponding author), Gu T. Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles. BMC Genomics. 2022;23(1):804. 2022 IF=4.4.
13. Zhang X, Zhao H, Li Y, Zhang Y, Liang Y, Shi J, Zhou R, Hong L, Cai G, Wu Z, Li Z (Corresponding author). Amphiregulin Supplementation During Pig Oocyte In Vitro Maturation Enhances Subsequent Development of Cloned Embryos by Promoting Cumulus Cell Proliferation. Cell Reprogram. 2022;24(4):175-185. 2021 IF=2.257.
14. Yang L, Wu X, Zhang N, Shi J, Zhou R, Su Q, Zheng E, Huang S, Xu Z, Hong L, Gu T, Yang J, Yang H, Cai G, Wu Z, Li Z (Corresponding author). Knockdown of RLIM inhibits XIST expression and improves developmental competence of cloned male pig embryos. Mol Reprod Dev. 2021 Mar;88(3):228-237.
15. Wu X, Zhao H, Lai J, Zhang N, Shi J, Zhou R, Su Q, Zheng E, Xu Z, Huang S, Hong L, Gu T, Yang J, Yang H, Cai G, Wu Z, Li Z (Corresponding author). Interleukin 17D Enhances the Developmental Competence of Cloned Pig Embryos by Inhibiting Apoptosis and Promoting Embryonic Genome Activation. Animals (Basel). 2021 Oct 26;11(11):3062.
16. Ao Z, Wu Z, Zhao H, Wu Z, Li Z (Corresponding author). Associations of cord metabolome and biochemical parameters with the neonatal deaths of cloned pigs. Reprod Domest Anim. 2021 Dec;56(12):1519-1528.
17. Ao Z, Gu T, Zhao H, Shi J, Zheng E, Cai G, Wu Z, Li Z (Corresponding author). The pathophysiological changes associated with neonatal death of cloned pigs. Reproduction. 2020 Aug;160(2):193-203.
18. Zeng F, Zhao C, Wu X, Dong R, Li G, Zhu Q, Zheng E, Liu D, Yang J, Moisyadi S, Urschitz J, Li Z (Corresponding author), Wu Z. Bacteria-induced expression of the pig-derived protegrin-1 transgene specifically in the respiratory tract of mice enhances resistance to airway bacterial infection. Scientific Report. 2020 Sep 29;10(1):16020.
19. Huang X, Zou X, Xu Z, Tang F, Shi J, Zheng E, Liu D, Moisyadi S, Urschitz J, Wu Z, Li Z (Corresponding author). Efficient deletion of LoxP-flanked selectable marker genes from the genome of transgenic pigs by an engineered Cre recombinase. Transgenic Res. 2020 Jun;29(3):307-319.
20. Zhao H, Xie S, Zhang N, Ao Z, Wu X, Yang L, Shi J, Mai R, Zheng E, Cai G, Wu Z, Li Z (Corresponding author). Source and Follicular Fluid Treatment During the In Vitro Maturation of Recipient Oocytes Affects the Development of Cloned Pig Embryo. Cellular Reprogramming. 2020 Apr;22(2):71-81
21. Ao Z, Li Z (Co-first author), Wang X, Zhao C, Gan Y, Wu X, Zeng F, Shi J, Gu T, Hong L, Zheng E, Liu D, Xu Z, Wu Z, Cai G. Identification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses. Molecular Reproduction and Development. 2019. 86(3):278-291.
22. Yang X, Wu X, Yang Y, Gu T, Hong L, Zheng E, Xu Z, Zeng F, Shi J, Zhou R, Cai G, Wu Z, Li Z (Corresponding author). Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression. Journal of Reproduction and Development. 2019. 65(6):533-539.
23. Ao Z, Wu X, Zhou J, Gu T, Wang X, Shi J, Zhao C, Cai G, Zheng E, Liu D, Wu Z, Li Z (Corresponding author). Cloned pig fetuses exhibit fatty acid deficiency from impaired placental transport. Molecular Reproduction and Development. 2019. 86(11):1569-1581.
24. Tang F, Yang X, Liu D, Zhang X, Huang X, He X, Shi J, Li Z (Co-corresponding author), Wu Z. Co-expression of fat1 and fat2 in transgenic pigs promotes synthesis of polyunsaturated fatty acids. Transgenic Research. 2019. 28(3-4):369-379 .
25. Wang X, Shi J, Cai G, Zheng E, Liu D, Wu Z, Li Z (Corresponding author). Overexpression of MBD3 Improves Reprogramming of Cloned Pig Embryos. Cellular Reprogramming. 2019. 21(5):221-228
26. Zhang X, Li Z (Co-first author), Yang H, Liu D, Cai G, Li G, Mo J, Wang D, Zhong C, Wang H, Sun Y, Shi J, Zheng E, Meng F, Zhang M, He X, Zhou R, Zhang J, Huang M, Zhang R, Li N, Fan M, Yang J, Wu Z. Novel transgenic pigs with enhanced growth and reduced environmental impact. eLife. 2018, 7: e34286.
27. Li Z (First author), Yue Z, Ao Z, Zhao C, Shi J, Zhao C, Zeng F, Cai G, Zheng E, Yang J, Gu T, Yang H, Hong L, Xu Z, Liu D, Wu Z. Maternal dietary supplementation of arginine increases the ratio of total cloned piglets born to total transferred cloned embryos by improving the pregnancy rate of recipient sows. Animal Reproduction Science. 2018, 196:211-218.
28. Zeng F, Dong R, Zhao C, Liu D, Zheng E, Song C, Wu Z, Li Z (Corresponding author). Constitutive expression of antimicrobial peptide PR-39 in transgenic mice significantly enhances resistance to bacterial infection and promotes growth. Transgenic Research. 2018, 27(5):409-422.
29. Zeng F, Li Z (Co-first author), Zhu Q, Dong R, Zhao C, Li G, Li G, Gao W, Jiang G, Zheng E, Cai G, Moisyadi S, Urschitz J, Yang H, Liu D, Wu Z. Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors. Scientific Reports. 2017, 7:41270.
30. Zheng Ao, Dewu Liu, Chengfa Zhao, Zhimin Yue, Junsong Shi, Rong Zhou, Gengyuan Cai, Enqin Zheng, Zicong Li (Co-corrresponding author), Zhenfang Wu. Birth weight, umbilical and placental traits in relation to neonatal loss in cloned pigs. Placenta. 2017, 57: 94-101.
31. Yang Y, Wu D, Liu D, Shi J, Zhou R, He X, Quan J, Cai G, Zheng E, Wu Z, Li Z (Corresponding author). Mutation of the XIST gene up-regulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos. Molecular Reproduction and Development. 2017, 84(6):525-534.
32. Zeng F, Huang Z, Yuan Y, Shi J, Cai G, Liu D, Wu Z, Li Z (Corresponding author). Effects of RNAi-mediated knockdown of Xist on the developmental efficiency of cloned male porcine embryos. Journal of Reproduction and Development. 2016, 62(6) :591-597.
33. Shi J, Zhou R, Luo L, Mai R, Zeng H, He X, Liu D, Zeng F, Cai G, Ji H, Tang F, Wang Q, Wu Z, Li Z (Corresponding author). Influence of embryo handling and transfer method on pig cloning efficiency. Animal Reproduction Science. 2015. 154: 121-127.
34. Xu W, Li Z (Corresponding author), Ouyang Z, Yu B, Shi J, Liu D, Wu Z. RNA-Seq transcriptome ananlysis of porcine cloned and in vitro fertilized blastocysts. Journal of Integrative Agriculture. 2015. 14(5):60345-7.
35. Zhang X, Li Z (Co-first author), Meng F, Wang D, Liu D, He X, Sun Y, Bai Y, Wu Z. Characterization of dual enzyme resulted from bicistronic expression of two β-glucanases. Journal of Integrative Agriculture. 2015. 14(4):732-740.
36. Li Z (First author), Zeng F, Meng F, Xu Z, Zhang X, Huang X, Tang F, Gao W, Shi J, He X, Liu D, Wang C, Urschitz J, Moisyadi S, Wu Z. Generation of transgenic pigs by cytoplasmic injection of piggyBac transposase based pmGENIE-3 plasmids. Biology of Reproduction. 2014. 90(5):93, 1–10.
37. Wu Z, Xu Z, Zou X, Zeng F, Shi J, Liu D, Urschitz J, Moisyadi S, Li Z (Corresponding author), Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer. Transgenic Research. 2013.22:1107-1118.
38. Li Z (First author), He X, Chen L, Shi J, Zhou R, Xu W, Liu D, Wu Z. Bone marrow mesenchymal stem cells are an attractive donor cell type for production of cloned pigs as well as genetically modified cloned pigs by somatic cell nuclear transfer. Cellular Reprogramming. 2013, 15(5):459-70.
39. Li Z (First author),  Shi J, Liu D, Zeng H, Zhou X, Mai R, Zhou R, Zeng S, Luo L, Yu W,  Zhang S, Wu Z. Effects of donor fibroblast cell type and transferred cloned embryo number on the efficiency of pig cloning. Cellular Reprogramming.  2013. 15(1):35-42.
40. Li Z (First author), Wu Z, Ren G, Zhao Y, Liu D. Expression patterns of insulin-like growth factor system members and their correlations with growth and carcass traits in Landrace and Lantang pigs during postnatal development. Molecular Biology Reports. 2013. 40(5):3569-76.
41. Xu W, Li Z(Co-first author), Yu B, He X, Shi J, Zhou R, Liu D, Wu Z. Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear Transfer. PLoS ONE。 2013. 8(5): e64705.
42. Wang K, Li Z (Co-first author), Li Y, Zeng J, He C, Yang J, Liu D, Wu Z. Muscle-specific transgenic expression of porcine myostatin propeptide enhances muscle growth in mice. Transgenic Research. 2013. 22(5):1011-9.
43. Li Z (First author), Zeng F, Mitchell A, Kim YS, Wu Z, Yang J. Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone formation. Biochemical and Biophysical Research Communications. 2011; 416: 289-92.
44. Li Z (First author), Kawasumi M, Zhao B, Moisyadi S, Yang J. Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra. Molecular Reproduction and Development. 2010; 77: 990-7.
45. Li Z (First author), Zhao B, Kim YS, Hu CY and Yang J. Administration of a mutated myostatin propeptide to neonatal mice significantly enhances skeletal muscle growth. Molecular Reproduction and Development. 2010; 77: 76-82.
46. Li Z (First author), Cao B, Zhao B, Yang X, Fan MZ, Yang J. Decreased expression of calpain and calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal pigs. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 2009; 152: 498-503.
科研创新
1、转基因动物的制备方法,专利号:201310737657.1。
2、抗猪圆环病毒2型的表达载体和转基因猪及其构建方法,专利号:201310321355.6。
3、一种转Δ12和Δ15脂肪酸去饱和酶基因猪及其制备方法和应用,专利号:201610357134.8。
4、唾液腺组织特异性的转基因载体及其构建方法,专利号:201310343067.0。
5、唾液腺组织特异性表达外源蛋白的转基因载体和转基因猪及其构建方法,专利号:201310343271.2。
6、一种收集动物腮腺唾液的装置,专利号:201320875886.5。
7、一种动物唾液采集装置,专利号:201420846901.8。
8、一种多顺反子、唾液腺特异性表达多顺反子的载体及其构建方法,201610397567.6
9、可在动物细胞表达分泌的重组葡聚糖酶及其重组方法和应用,专利号:20140161721.0。
10、一种基于对Rbmy基因进行编辑来实现动物性别控制的方法和应用专利号:201610307611.X。
11、对X染色体多拷贝基因进行编辑实现动物性别控制的方法,专利号:202010338934.1。
12、一种利用小分子化合物提高基因组定点插入效率的方法,专利号:201910782047.0。
13、一种利用修饰的ssODN提高细胞基因组定点修饰效率的方法,专利号:201910782035。
14、一种利用小分子化合物提高基因组定点修饰效率的方法,专利号:201910782039.6。
15、一种提高基因组定点修饰效率的方法,专利号:201910782049.X。
16、提高基因组定点整合效率的抑制剂及其应用,专利号:202010116317.7。
17、一种定点整合外源DNA转基因猪的构建方法,专利号:201711477805.5。
18、猪Xist基因序列、猪anti-Xist siRNA 序列及通过抑制猪Xist基因表达提高猪克隆效率的方法,专利号:201210543946.3。
19、一种基于获取特定供体细胞提高哺乳动物克隆效率的方法,专利号:201810556066.7。
20、一种提高克隆胚胎发育质量的添加剂及其应用,专利号:202110626164.5。
21、一种克隆胚胎处理液及其使用方法以及该处理液的用途,专利号:201710339889.X。
22、提高卵母细胞体外成熟质量的添加剂、培养方法及应用,专利号:202110783854.1。
23、促进卵母细胞体外成熟的添加剂及其应用,专利号:202110783855.6。
24、一种卵母细胞体外成熟培养液及其应用,专利号:202110784670.7。
25、一种卵母细胞培养液及提高卵母细胞质量的体外培养方法,专利号:201911231323.0。
26、卵母细胞体外成熟培养液添加剂、培养液及其应用,专利号:202110624594.3。
27、猪SIRT1基因的表达抑制剂及其应用,专利号:201911337465.5。
28、猪HDAC2基因的表达抑制剂及其应用,专利号:201911338990.9。
29、一种培养猪滋养层干细胞的专用培养基及其方法,专利号:201510210334.6。
30、促进骨骼肌发育的方法和促进骨骼肌发育的抑制剂及应用,专利号:202010736671.X。
31、调节骨骼肌发育的方法和应用,专利号:202010736669.2。
32、促进骨骼肌发育的方法和应用,专利号:202010736684.7。
33、一种影响猪肌内脂肪性状的分子标记及应用,专利号:201610113646.X。
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